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KMID : 0043320120350071127
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Archives of Pharmacal Research
2012 Volume.35 No. 7 p.1127 ~ p.1131
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Metabolites from the mangrove-derived fungus Xylaria cubensis PSU-MA34
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Klaiklay Saranyoo
Rukachaisirikul Vatcharin
Sukpondma Yaowapa
Phongpaichit Souwalak
Buatong Jirayu
Bussaban Boonsom
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Abstract
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Two new succinic acid derivatives, xylacinic acids A (1) and B (2), along with seven known compounds, including one succinic acid derivative (3), three mellein derivatives (4?6), cytochalasin D (7), 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (8) and isosclerone (9), were isolated from the mangrove-derived fungus Xylaria cubensis PSU-MA34. Their structures were established by spectroscopic evidence. They were evaluated for cytotoxicity against KB cells and antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus.
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KEYWORD
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Xylaria cubensis, Mangrove-derived fungus, Succinic acid, Mellein, Cytotoxicity, Antibacterial activity
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